Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.
نویسندگان
چکیده
A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.
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عنوان ژورنال:
- Chemical communications
دوره 48 43 شماره
صفحات -
تاریخ انتشار 2012